Réaction #554643

ord-e2a0d5eb27f54a2c8c9fae9d97057072

Équation de réaction

Oc1ccc(Br)cc1
4-bromophenol
ClCC1CC1
(chloromethyl)cyclopropane
O=C([O-])[O-].[K+].[K+]
K2CO3
CN(C)C=O
DMF
→
Brc1ccc(OCC2CC2)cc1
1-Bromo-4-cyclopropylmethoxybenzene

Réactifs

Oc1ccc(Br)cc1
4-bromophenol
ClCC1CC1
(chloromethyl)cyclopropane
O=C([O-])[O-].[K+].[K+]
K2CO3
CN(C)C=O
DMF

Réactifs

Aucun

Solvants

O
water

Conditions de réaction

Température
80°CELSIUS
Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Extractionextracted with DCM
  2. 2
    SéchageThe organic layer is dried with MgSO4
  3. 3
    Filtrationfiltered
  4. 4
    Autrethe solvent is removed in vacuo

Mode opératoire

5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried with MgSO4, filtered and the solvent is removed in vacuo.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08623860B2uspto-grants-2014_01