Réaction #554641

Équation de réaction

acetic anhydride

1-(4-bromophenyl)propane-2-amine

→

N-(1-(4-Bromophenyl)propan-2-yl)acetamide

Solvants

AcOH

Conditions de réaction

Traitement

1. 1
   AutreThe solvent is evaporated in vacuo
2. 2
   AutreThe layers are separated
3. 3
   Lavagethe organic layer is washed with water
4. 4
   Séchagedried with Na2SO4
5. 5
   Filtrationfiltered
6. 6
   Autrethe solvent is removed in vacuo
7. 7
   AutreThe crude product is triturated with DIPE

Mode opératoire

17.0 mL (179.7 mmol) acetic anhydride are added to a mixture of 24.2 g (113 mmol) 1-(4-bromophenyl)propane-2-amine and 20 mL AcOH and the reaction mixture is stirred at r.t. over night. The solvent is evaporated in vacuo, and the residue partitonated between TBME and a saturated aq. NaHCO3 solution. The layers are separated and the organic layer is washed with water, dried with Na2SO4, filtered and the solvent is removed in vacuo. The crude product is triturated with DIPE.

Source