Réaction #554640

Équation de réaction

4-bromophenylacetone

ammonia

hydrogen

→

1-(4-Bromophenyl)propane-2-amine

Solvants

MeOH

Conditions de réaction

Traitement

1. 1
   AutreAfter complete reaction
2. 2
   Filtrationthe mixture is filtrated
3. 3
   LavageThe residue is washed with MeOH
4. 4
   Autrethe solvent of the filtrate is removed in vacuo
5. 5
   AutreThe crude product is used without further purification

Mode opératoire

A mixture of 25.0 g (0.12 mol) 4-bromophenylacetone and 400 mL 7N ammonia in MeOH is charged with 1.20 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (15 psi) at r.t. over night. Again 0.6 g Raney nickel are added and the mixture is stirred again for 3.5 h. After complete reaction, the mixture is filtrated. The residue is washed with MeOH and the solvent of the filtrate is removed in vacuo. The crude product is used without further purification.

Source