Réaction #554567

Équation de réaction

Phosphorus oxychloride

dimethylaniline

phenanthridine

→

9-chlorophenanthridine

Rendement 96.0%

Solvants

H2O

Conditions de réaction

Traitement

1. 1
   Températureby refluxing for 3 hours
2. 2
   Extractionthe obtained solid was extracted with chloroform
3. 3
   Séchageby drying with sodium sulfate
4. 4
   FiltrationAfter filtration
5. 5
   Autrethe filtrate was evaporated to dryness under reduced pressure
6. 6
   AutreThe obtained solid was purified by column chromatography (eluent: chloroform) (amount: 2.1 g, yield: 96%)

Mode opératoire

Phosphorus oxychloride (15 ml) and dimethylaniline (0.63 ml) were added to phenanthridine (2.0 g), followed by refluxing for 3 hours. The solution was poured into H2O to generate a solid, and the obtained solid was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 2.1 g, yield: 96%).

Source