Réaction #554566

Équation de réaction

H2O

Benzo[b]thiophene-2-ylboronic acid

1-chloroisoquinoline

sodium carbonate

→

1-Benzothienylisoquinoline

Rendement 79.0%

Solvants

toluene

ethanol

Conditions de réaction

Traitement

1. 1
   Températureby refluxing under a N2 atmosphere for 5 hours
2. 2
   Extractionthe mixture was extracted with chloroform
3. 3
   Séchageby drying with sodium sulfate
4. 4
   FiltrationAfter filtration
5. 5
   Autrethe filtrate was evaporated to dryness under reduced pressure
6. 6
   AutreThe obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.16 g, yield: 79%)

Mode opératoire

Benzo[b]thiophene-2-ylboronic acid (997 mg, 5.6 mmol) and 1-chloroisoquinoline (946 mg, 5.8 mmol) were dissolved in toluene (20 ml) and ethanol (10 ml), and palladium catalyst (220 mg, 0.19 mmol) and 2M sodium carbonate solution (20 ml) were added thereto, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O, and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.16 g, yield: 79%).

Source