Réaction #5535

Équation de réaction

5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

hydrogen chloride methanol

→

desired product

Rendement 89.3%

5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride

Rendement 89.3%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   workup.DISTILLATIONAfter the solvent was distilled off
2. 2
   Autrethe residue was crystallized from chloroform ether
3. 3
   AutreThen, the crystals thus obtained
4. 4
   Lavagewere washed with ether
5. 5
   Autredried

Mode opératoire

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

Source