Réaction #553080

Équation de réaction

3-mercapto propyl amine

glutaric anhydride

→

N-(3-mercapto propyl) glutaramic acid

Rendement 126.7%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Températurewhile maintaining the temperature of the reaction mixture lower than 40° C
2. 2
   workup.STIRRINGAfter stirring for 6 hours 30 minutes the reaction
3. 3
   AutreThe solution is evaporated to dryness under reduced pressure
4. 4
   AutreThe product is then dried under a vacuum at a temperature lower than 60° C.

Mode opératoire

To a solution of 6.84 g (0.075 mole) of 3-mercapto propyl amine (homocysteamine) in 20 cm3 of methanol, maintained under an inert atmosphere and stirred at ambient temperature, there are added, by portions, 8.56 g (0.075 mole) of glutaric anhydride while maintaining the temperature of the reaction mixture lower than 40° C. After stirring for 6 hours 30 minutes the reaction is complete. The solution is evaporated to dryness under reduced pressure. The product is then dried under a vacuum at a temperature lower than 60° C. and 19.5 g of N-(3-mercapto propyl) glutaramic acid are obtained in the form of a colorless oil.

Source