Réaction #55251

Équation de réaction

methanol

methanol

3-ethynylphenyl(p-toluenesulfonate)

potassium hydroxide

4-nitronaphthalic anhydride

→

4-(3-ethynylphenoxy)naphthalic anhydride

Rendement 80.0%

Solvants

N,N-dimethylacetamide

methylene chloride

diethylether

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was heated
2. 2
   Températureto reflux, under a nitrogen atmosphere
3. 3
   Températuremaintained
4. 4
   Températureat reflux for four hours
5. 5
   workup.DISTILLATIONwas distilled from the flask until the residue
6. 6
   workup.ADDITIONThen, 400 ml of anhydrous benzene was added
7. 7
   workup.DISTILLATIONdistillation
8. 8
   Autrewas removed
9. 9
   AutreThe reaction mixture was freeze-dried under high vacuum
10. 10
    Autreleaving a dry, white powder
11. 11
    workup.ADDITIONTo the freeze-dried material was added a solution
12. 12
    Températuremaintained at that temperature for 12 hours
13. 13
    Températureto cool to room temperature
14. 14
    Autreto precipitate the inorganic salts which
15. 15
    Autrewere removed by filtration
16. 16
    AutreThe diethylether/DMAC solvent was removed in vacuo at 90° C., by means of a rotary evaporator
17. 17
    Autreleaving a residual oil
18. 18
    Filtrationfiltered through a 2"×6"
19. 19
    Autredry column of silica gel
20. 20
    Lavagewhile eluting the column with methylene chloride
21. 21
    AutreThe eluate was evaporated to dryness

Mode opératoire

To 100 ml of anhydrous methanol was added 20 g (0.073 mole) of 3-ethynylphenyl(p-toluenesulfonate) and 8.19 g (0.146 mole) of potassium hydroxide. The mixture was heated to reflux, under a nitrogen atmosphere and maintained at reflux for four hours. A distillation apparatus was attached to the flask, and methanol was distilled from the flask until the residue approached dryness. Then, 400 ml of anhydrous benzene was added, and distillation continued until 200 ml of benzene was removed. The reaction mixture was freeze-dried under high vacuum, leaving a dry, white powder. To the freeze-dried material was added a solution containing 12.1 g (0.05 mole) of 4-nitronaphthalic anhydride dissolved in 300 ml of anhydrous N,N-dimethylacetamide (DMAC). The mixture was heated to 100° C., under a nitrogen atmosphere, and maintained at that temperature for 12 hours. The reaction mixture was allowed to cool to room temperature and poured into diethylether to precipitate the inorganic salts which were removed by filtration. The diethylether/DMAC solvent was removed in vacuo at 90° C., by means of a rotary evaporator leaving a residual oil. The oil was dissolved in methylene chloride and filtered through a 2"×6" dry column of silica gel while eluting the column with methylene chloride. The eluate was evaporated to dryness, yielding 12.5 g (80%) of 4-(3-ethynylphenoxy)naphthalic anhydride.

Source