Réaction #55096

Équation de réaction

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

→

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride

Rendement 164.7%

Solvants

isopropyl alcohol

hydrochloric acid

Conditions de réaction

Traitement

1. 1
   Températureunder reflux for 17 hours
2. 2
   ConcentrationConcentration
3. 3
   Autrefollowed by re-evaporation with water
4. 4
   Autreafforded a residue which
5. 5
   Concentrationconcentrated to low bulk
6. 6
   Températurecooled

Mode opératoire

A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in concentrated aqueous hydrochloric acid (450 ml.) was heated under reflux for 17 hours. Concentration followed by re-evaporation with water afforded a residue which was dissolved in isopropyl alcohol, concentrated to low bulk and cooled to afford 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (40.6 g.), m.p. 185°-191°.

Source