Réaction #54985

Équation de réaction

2-chloro-5-trifluoromethyl-aniline

ethoxymethylenemalononitrile

→

N-(2,2-dicyanovinyl)-2-chloro-5-trifluoromethylaniline

Rendement 70.0%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurethe mixture is refluxed for 48 hours
2. 2
   TempératureAfter cooling
3. 3
   Filtrationthe precipitated product is collected by filtration
4. 4
   Lavagewashed with ethanol
5. 5
   AutreRecrystallisation from ethanol
6. 6
   Autreaffords the above product with a melting point of 166°-169° C.

Mode opératoire

19.6 Parts of 2-chloro-5-trifluoromethyl-aniline and 12.2 parts of ethoxymethylenemalononitrile are dissolved in 125 parts of ethanol and the mixture is refluxed for 48 hours. After cooling, the precipitated product is collected by filtration and washed with ethanol. Recrystallisation from ethanol affords the above product with a melting point of 166°-169° C. and in a 70% yield.

Source