Réaction #5481

Équation de réaction

n-butyllithium hexane

1-azabicyclo[3.3.1]nonane-5-methanol

4-amino-5-chloro-2-methoxybenzoic acid

1,1'-carbonyldiimidazole

→

pale yellow solid

Rendement 57.3%

4-Amino-5-chloro-2-methoxybenzoic acid 1-azabicyclo[3.3.1]non-5-ylmethyl ester

Rendement 57.3%

Solvants

tetrahydrofuran

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   Autredegassed with a stream of nitrogen over 10 minutes
2. 2
   workup.STIRRINGstirred for 30 minutes
3. 3
   Concentrationconcentrated in vacuo
4. 4
   AutreThe above prepared suspension
5. 5
   workup.STIRRINGthe mixture was stirred overnight (18 hours)
6. 6
   Concentrationconcentrated in vacuo
7. 7
   AutreThe residue was partitioned between methylene chloride (100 mL)
8. 8
   workup.ADDITIONcontaining a little 2-propanol and saturated aqueous sodium carbonate (50 mL)
9. 9
   Autrethe organic layer was separated
10. 10
    ExtractionThe aqueous solution was extracted with methylene chloride (2×50 mL)
11. 11
    Séchagethe combined organic solution was dried (Na2SO4)
12. 12
    Concentrationconcentrated in vacuo
13. 13
    Autrerecrystallized from acetonitrile (2 crops)

Mode opératoire

A solution of 4-amino-5-chloro-2-methoxybenzoic acid (2.02 g, 10 mmol) in anhydrous tetrahydrofuran (10 mL) under nitrogen was treated with 1,1'-carbonyldiimidazole (1.70 g, 10.5 mmol), stirred for one hour, then degassed with a stream of nitrogen over 10 minutes. Meanwhile, a cooled (-10° C.) solution of 1-azabicyclo[3.3.1]nonane-5-methanol (1.71 g, 11 mmol) in anhydrous tetrahydrofuran (10 mL) under nitrogen was treated (via syringe) with 2.5N n-butyllithium/hexane (10.7 mmol), stirred for 30 minutes, concentrated in vacuo, and taken up in anhydrous tetrahydrofuran (10 mL) under nitrogen. The above prepared suspension was transferred into this solution, and the mixture was stirred overnight (18 hours) and concentrated in vacuo. The residue was partitioned between methylene chloride (100 mL) containing a little 2-propanol and saturated aqueous sodium carbonate (50 mL), and the organic layer was separated. The aqueous solution was extracted with methylene chloride (2×50 mL), and the combined organic solution was dried (Na2SO4), concentrated in vacuo and recrystallized from acetonitrile (2 crops) to afford 1.94 g (57%) of pale yellow solid; mp 152.5°-154.5° C.

Source