Réaction #54594

Équation de réaction

2,5-dimethoxytetrahydrofuran

sodium acetate

α-sulfo-α-aminoacetic acid hydrochloride

→

α-sulfo-α-(1-pyrryl) acetic acid

Solvants

acetic acid

ethylacetate

acetic acid

Conditions de réaction

Traitement

1. 1
   TempératureThe solution is heated
2. 2
   Températureto reflux for 5 minutes
3. 3
   Températurerefluxed for an additional 2 minutes
4. 4
   Autreevaporated
5. 5
   Autreleaving a residue which
6. 6
   FiltrationThe ethyl acetate is filtered
7. 7
   Autredried
8. 8
   Autreevaporated

Mode opératoire

To a solution of sodium acetate (0.1 mole) in about 300 ml of glacial acetic acid is added about 0.05 mole of α-sulfo-α-aminoacetic acid hydrochloride. The solution is heated to reflux for 5 minutes, 2,5-dimethoxytetrahydrofuran (1 equivalent based on α-sulfo-α-aminoacetic acid hydrochloride) is added as quickly as possible, and the solution refluxed for an additional 2 minutes. The acetic acid is flash evaporated leaving a residue which is taken up in ethylacetate. The ethyl acetate is filtered, dried and evaporated to give α-sulfo-α-(1-pyrryl) acetic acid.

Source