Réaction #5430

Équation de réaction

potassium hydroxide

4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide

→

5-tert-Butylaminocarbonyl-2-methylthiothiazole-4-carboxylic acid

Solvants

water

water ethanol

Conditions de réaction

Traitement

1. 1
   Températurethe mixture was refluxed for 2 hours
2. 2
   AutreThe solvent mixture was then removed under reduced pressure
3. 3
   FiltrationThe precipitated product was filtered off
4. 4
   Autredried

Mode opératoire

0.82 g (14.6 mmol) of potassium hydroxide in 10 ml of water was added to a solution of 4.00 g (13.2 mmol) of 4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide in 50 ml of water/ethanol (2:1), and the mixture was refluxed for 2 hours. The solvent mixture was then removed under reduced pressure and the residue was taken up in 50 ml of water and acidified with concentrated hydrochloric acid. The precipitated product was filtered off and dried.

Source