Réaction #54279

Équation de réaction

hydrogen

1-(3,4-methylenedioxyphenyl)-2-aminoethanol hydrochloride

acetaldehyde

→

1-(3,4-methylenedioxyphenyl)-2-ethylaminoethanol hydrochloride

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONTo the resulting solution are added 0.5 g
2. 2
   AutreAfter the absorption of hydrogen
3. 3
   Températurethe mixture is cooled
4. 4
   FiltrationThen the catalyst is filtered off
5. 5
   Concentrationthe filtrate is concentrated to dryness
6. 6
   AutreUpon recrystallization of the crude crystalline residue from isopropyl alcohol, 12.5 g

Mode opératoire

18 g. of 1-(3,4-methylenedioxyphenyl)-2-aminoethanol hydrochloride are dissolved in 300 ml. of ethanol and 50 ml. of 80% aqueous solution of acetaldehyde. To the resulting solution are added 0.5 g. of extended Raney nickel and the mixture is heated at 70° C. in an atmosphere of hydrogen in a 1 liter-autoclave. After the absorption of hydrogen is complete, the mixture is cooled. Then the catalyst is filtered off and the filtrate is concentrated to dryness. Upon recrystallization of the crude crystalline residue from isopropyl alcohol, 12.5 g. of 1-(3,4-methylenedioxyphenyl)-2-ethylaminoethanol hydrochloride are obtained as white needles.

Source