Réaction #54276

Équation de réaction

1-(3,4-methylenedioxyphenyl)-2-aminoethanol hydrochloride

acetone

hydrogen

→

1-(3,4-methylenedioxyphenyl)-2-isopropylaminoethanol hydrochloride

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONTo the resulting solution are added 10 g
2. 2
   AutreAfter the absorption of hydrogen
3. 3
   Filtrationthe catalyst is filtered off
4. 4
   Concentrationthe filtrate is concentrated to dryness
5. 5
   AutreUpon recrystallization of the crude crystalline residue from isopropyl alcohol, 14.4 g

Mode opératoire

18.1 g. of 1-(3,4-methylenedioxyphenyl)-2-aminoethanol hydrochloride are dissolved in 20 ml. of acetone and 300 ml. of ethanol. To the resulting solution are added 10 g. of extended Raney nickel and the mixture is heated and stirred at 70° C. in an atmosphere of hydrogen in an autoclave. After the absorption of hydrogen is complete, the catalyst is filtered off and the filtrate is concentrated to dryness. Upon recrystallization of the crude crystalline residue from isopropyl alcohol, 14.4 g. of 1-(3,4-methylenedioxyphenyl)-2-isopropylaminoethanol hydrochloride are obtained as white needles.

Source