Réaction #54240

Équation de réaction

water

sodium hydride

2-(1,2,4-Triazol-1-yl)-4'-chloroacetophenone

α-methylbenzyl chloride

→

title compound

2-(1,2,4-Triazol-1-yl)-3-phenyl-4'-chlorobutyrophenone

Solvants

dimethylformamide

Conditions de réaction

Traitement

1. 1
   Autre(3 hours)
2. 2
   Températurethe mixture was cooled to 0°
3. 3
   workup.STIRRINGAfter stirring at room temperature for 20 hours
4. 4
   Filtrationthe product filtered off
5. 5
   AutreRecrystallisation from chloroform/petroleum ether (60°-80°)

Mode opératoire

2-(1,2,4-Triazol-1-yl)-4'-chloroacetophenone (0.01 mol) was dissolved in dimethylformamide (5.0 ml) at room temperature and treated with sodium hydride (0.01 mol). When the reaction was complete (3 hours), the mixture was cooled to 0° and α-methylbenzyl chloride (0.01 mol) was added dropwise with stirring. After stirring at room temperature for 20 hours, the mixture was poured into water and the product filtered off. Recrystallisation from chloroform/petroleum ether (60°-80°) gave the title compound as a colourless crystalline solid, m.p. 163°-5°.

Source