Réaction #5418

Équation de réaction

2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline

hydrochloric acid

→

2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline

Rendement 46.5%

Solvants

ethanol water

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 3 hours
2. 2
   AutreEthanol was removed by distillation under reduced pressure
3. 3
   Extractionextracted with ethyl acetate
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   AutreThe solvent was removed by distillation under reduced pressure

Mode opératoire

A mixture of 2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline (1 g) and hydrochloric acid (38 %, 4 ml) in ethanol-water (1:2, 15 ml) was refluxed for 3 hours. Ethanol was removed by distillation under reduced pressure, and the residue was neutralized with potassium carbonate, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 0.4 g of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound (xi)).

Source