Réaction #53932

Équation de réaction

NaOCl

sodium thiosulfat

NaOCl

cis-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid benzyl ester

KBr

NaHCO3

→

Methyl-(4-oxo-cyclohexyl)-carbamic acid benzyl ester

Rendement 99.0%

Solvants

CH2Cl2

water

Conditions de réaction

Traitement

1. 1
   ExtractionThe aqueous phase was extracted with CH2Cl2(2×)
2. 2
   Séchagethe organic phase was dried (Na2SO4)
3. 3
   Filtrationfiltered
4. 4
   Autreevaporated

Mode opératoire

A solution of 2.63 g (10 mmol) of cis-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid benzyl ester in 16 ml CH2Cl2 was treated with a solution 0.24 g (2 mmol) of KBr and 0.28 g (3.33 mmol) of NaHCO3 in 5 ml of water. The suspension was cooled (0-5° C.) and 8 mg (0.05 mmol) of TEMPO and then 5.7 ml (12.5 mmol) of NaOCl (13%, 2.18 M in water) were added during 20 min. After 1 h at this temperature, again 8 mg (0.05 mmol) of TEMPO and then 2.85 ml (6.25 mmol) of NaOCl (13%, 2.18 M in water) were added. After 1 h, 5 ml of 1M sodium thiosulfat solution was added. The aqueous phase was extracted with CH2Cl2(2×), the organic phase was dried (Na2SO4), filtered and evaporated to give 2.57 g (99%) of Methyl-(4-oxo-cyclohexyl)-carbamic acid benzyl ester, MS: 261 (M).

Source