Réaction #53881

ord-b16cec55f2074abf9cd51125741926ed

Équation de réaction

C=CCCN
N-allylmethylamine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-(trifluoromethyl)benzenesulphonyl chloride
→
C=CCN(C)CCCCC[C@H]1CC[C@H](N(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1
trans-N-{4-[5-(Allyl-methyl-amino)-pentyl]-cyclohexyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide

Réactifs

C=CCCN
N-allylmethylamine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-(trifluoromethyl)benzenesulphonyl chloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-(trifluoromethyl)benzenesulphonyl chloride were reacted, followed by treatment with N-allylmethylamine to yield trans-N-{4-[5-(Allyl-methyl-amino)-pentyl]-cyclohexyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 461 (MH+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06858651B2uspto-grants-2005_02