Réaction #53817

ord-6bcf74ab6ce04373a5f3ec962cac2747

Équation de réaction

CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](O)CC1
trans-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester
BrCCCCCCBr
1,6-dibromohexane
→
CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](OCCCCCCBr)CC1
trans-[4-(6-Bromo-hexyloxy)-cyclohexyl]-methyl-carbamic acid tert-butyl ester

Réactifs

CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](O)CC1
trans-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester
BrCCCCCCBr
1,6-dibromohexane

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

In analogy to examples 1.4 and 1.5, trans-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester was reacted with 1,6-dibromohexane to yield trans-[4-(6-Bromo-hexyloxy)-cyclohexyl]-methyl-carbamic acid tert-butyl ester which was reacted with N-allylmethylamine to yield trans-(4-[6-(Allyl-methyl-amino)-hexyloxy]-cyclohexyl)-methyl-carbamic acid tert-butyl ester as light brown oil, MS: 382 (M).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06858651B2uspto-grants-2005_02