Réaction #53786

Équation de réaction

HCl

1-Dodecanesulfonyl chloride

5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl-amine

5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenylamine

water

→

product

Rendement 44.9%

Dodecane-1-sulfonic acid [5-(5,6-difluoro-1H-indol-2-yl)-methoxy-phenyl]-amide

Rendement 44.9%

Solvants

pyridine

Conditions de réaction

Traitement

1. 1
   FiltrationAfter several hours the precipitate was filtered off
2. 2
   Lavagerinsed three times with water
3. 3
   Autredried
4. 4
   AutreRecrystallization from ethanol

Mode opératoire

1-Dodecanesulfonyl chloride (0.3 g, 1.1 mmol) was added to a stirred solution of 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl-amine from Example 3 (0.3 g, 1.11 mmol) in pyridine (3 mL) under an inert atmosphere at room temperature. After approximately 20 hours the mixture was poured into water (30 mL), stirred, and acidified with aqueous HCl. After several hours the precipitate was filtered off, rinsed three times with water, and dried. Recrystallization from ethanol afforded the product (0.25 g), mp 148-149° C.

Source