Réaction #5368

Équation de réaction

isopropanol

N,O-dimethylhydroxylamine hydrochloride

sodium bicarbonate

N-(bromoethyl)phthalimide

→

N-(2-chloroethyl)-phthalimide

Rendement 65.4%

Solvants

triethylamine

Conditions de réaction

Traitement

1. 1
   Températurethe mixture was refluxed for 29 hours
2. 2
   Extractionextracted with chloroform
3. 3
   AutreThe organic layer was separated
4. 4
   Lavagewas washed with water
5. 5
   Séchagedried over magnesium sulfate
6. 6
   workup.DISTILLATIONChloroform was distilled off
7. 7
   Autrethe residue was purified by column chromatography on silica gel

Mode opératoire

To a suspension of 50 ml of isopropanol containing N,O-dimethylhydroxylamine hydrochloride (3.90 g, 40.0 mmol) was added dropwise 5.56 ml of triethylamine. The resulting mixture became homogeneous after 5 minutes. Thereto was added 2.45 g (10.0 mmol) of N-(bromoethyl)phthalimide and the mixture was refluxed for 29 hours. This was cooled to room temperature, then poured into 200 ml of a saturated aqueous solution of sodium bicarbonate and extracted with chloroform. The organic layer was separated and was washed with water and dried over magnesium sulfate. Chloroform was distilled off and the residue was purified by column chromatography on silica gel. Development with 30% hexane-chloroform resulted in elution of 1.37 g of N-(2-chloroethyl)-phthalimide and further development with chloroform resulted in 0.964 g (yield: 41%) of white cyrstals of N-[2-(N-methoxy-N-methylamino)ethyl]phthalimide.

Source