Réaction #53340

Équation de réaction

compound XVIII

(±)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothiohydrazide

chloroform

methyl isocyanate

→

(±)-1-{8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

Rendement 88.0%

Conditions de réaction

Traitement

1. 1
   LavageAfter 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water
2. 2
   Concentrationafter concentration the obtained solid material
3. 3
   Autrewas purified
4. 4
   Températureby refluxing in ethanol

Mode opératoire

To a stirred solution of 0.40 g (1.0 mmol) of compound XVIII in 15 ml of chloroform 0.07 ml (1.2 mmol) of methyl isocyanate was added. After 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water and after concentration the obtained solid material was purified by refluxing in ethanol. The desired product was 0.36 g, yield: 88%. Mp.: 200° C.

Source