Réaction #5333

Équation de réaction

methyl 3-iodobenzoate

toluene

→

title compound

Rendement 29.0%

Methyl 4'-methylbiphenyl-3-carboxylate

Rendement 29.0%

Solvants

4-iodotoluene

Conditions de réaction

Traitement

1. 1
   FiltrationInsoluble materials were filtered off
2. 2
   Concentrationthe filtrate was concentrated to dryness
3. 3
   AutreThe residue was purified by column chromatography on silica gel

Mode opératoire

To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200°-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).

Source