Réaction #531893

Équation de réaction

4-benzyloxycarbonylamino-cyclohexanecarboxylic acid tert-butyl ester

hydrogen

→

4-amino-cyclohexanecarboxylic acid tert-butyl ester

Rendement 100.3%

Solvants

THF

Conditions de réaction

Traitement

1. 1
   FiltrationThe mixture is then filtered though celite
2. 2
   LavageThe celite is washed with MeOH (50 mL)
3. 3
   ConcentrationThe filtrated is concentrated

Mode opératoire

To a solution of 4-benzyloxycarbonylamino-cyclohexanecarboxylic acid tert-butyl ester (3.0 g, 9.009 mmol) in THF (80 mL) is added TEA (0.24 mL, 1.724 mmol) and 10% Pd/C (wet) (420 mg). The mixture stirs under a blanket of hydrogen gas at atmospheric pressure for 12 h. The mixture is then filtered though celite. The celite is washed with MeOH (50 mL). The filtrated is concentrated to afford 1.8 g of 4-amino-cyclohexanecarboxylic acid tert-butyl ester. LC/MS: [M+H]+ 200, Rt=0.39 min (method 6).

Source