Réaction #531834

Équation de réaction

N-butyl-N-methylamine

diisopropylcarbodiimide

diisopropylcarbodiimide

→

guanidine

Rendement 100.0%

1-Butyl-2,3-diisopropyl-1-methylguanidine

Rendement 100.0%

Conditions de réaction

Traitement

1. 1
   Températureis heated
2. 2
   Températureat reflux for 3 hours
3. 3
   Concentrationis concentrated at 60° C. under 5 mbar for 2 hours
4. 4
   Autreto give 40 g of a colorless and virtually odorless liquid of low viscosity, which

Mode opératoire

A mixture of 32.68 g of N-butyl-N-methylamine (0.375 mol) and 23.66 g of diisopropylcarbodiimide (0.1875 mol) is heated at reflux for 3 hours. GC analysis then shows a conversion of more than 99.5% of the diisopropylcarbodiimide. The final mixture, which is colorless, is concentrated at 60° C. under 5 mbar for 2 hours, to give 40 g of a colorless and virtually odorless liquid of low viscosity, which corresponds to the expected guanidine (100% yield).

Source