Réaction #531833

Équation de réaction

N-butylamine

diisopropylcarbodiimide

diisopropylcarbodiimide

→

guanidine

Rendement 96.7%

1-Butyl-2,3-diisopropylguanidine

Rendement 96.7%

Conditions de réaction

Traitement

1. 1
   Températureis heated
2. 2
   Températureat reflux for 3 hours 30 minutes
3. 3
   Concentrationis concentrated at 60° C. under 20 mbar for 2 hours
4. 4
   Autreto give 29 g of a colorless and virtually odorless liquid of low viscosity, which

Mode opératoire

A mixture of 33 g of N-butylamine (0.45 mol) and 19 g of diisopropylcarbodiimide (0.15 mol) is heated at reflux for 3 hours 30 minutes. GC analysis then shows a conversion of more than 99.5% of the diisopropylcarbodiimide. The final mixture, which is colorless, is concentrated at 60° C. under 20 mbar for 2 hours, to give 29 g of a colorless and virtually odorless liquid of low viscosity, which corresponds to the expected guanidine (96.7% yield).

Source