Réaction #531790

Équation de réaction

Mercaptopropionic acid

Triphenylmethylchloride

→

3-(tritylthio)propanoic acid

Rendement 95.7%

3-(tritylthio) propanoic acid

Rendement 95.7%

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   Autrewere carried out at room temperature
2. 2
   Filtrationwas filtered
3. 3
   Lavagewas rinsed with 40 ml of diethyl ether
4. 4
   AutreThe precipitate was then dried under reduced pressure

Mode opératoire

Mercaptopropionic acid 2 (3.14 g) was dissolved in 50 ml of methylene chloride. Triphenylmethylchloride 3 (8.36 g, 30 mmol) was added to that, and 19-hour protection reactions were carried out at room temperature. The precipitate generated through the protection reactions was filtered and gathered, and was rinsed with 40 ml of diethyl ether. The precipitate was then dried under reduced pressure, to form 9.86 g of 3-(tritylthio)propanoic acid 4, which is a white solid.

Source