Réaction #53108

ord-9f69a711b970455692ef10d697bfcbc0

Équation de réaction

$CC(C)(C)OC(=O)NCC(=O)NCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1$

(Z)-3-[1-(4-tert.butoxycarbonylaminomethylcarbonylaminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone

ethyl acetate hydrogen chloride

→

$Cl.NCC(=O)NCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1$

(Z)-3-[1-(4-aminomethylcarbonylaminomethyl-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone-hydrochloride

Réactifs

$CC(C)(C)OC(=O)NCC(=O)NCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1$

(Z)-3-[1-(4-tert.butoxycarbonylaminomethylcarbonylaminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone

ethyl acetate hydrogen chloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées

See reaction.notes.procedure_details.

Mode opératoire

Prepared analogously to Example 29a from (Z)-3-[1-(4-tert.butoxycarbonylaminomethylcarbonylaminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone and ethyl acetate/hydrogen chloride.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06855710B2uspto-grants-2005_02