Réaction #5310

Équation de réaction

Dihydropyran

4-chlorobutanol

→

title compound

Rendement 89.9%

2-[(4-Chlorobutyl)oxy]tetrahydropyran

Rendement 89.9%

Conditions de réaction

Traitement

1. 1
   Lavagewashed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
2. 2
   TempératureThe dried liquid was heated under reduced pressure

Mode opératoire

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

Source