Réaction #53096

ord-de6103e3f9ae4d69b00d1aa8b0d18b7a

Équation de réaction

CCOC(=C1C(=O)N(C(C)=O)c2ccc([N+](=O)[O-])cc21)c1ccccc1
1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone
CN1CCN(CC(=O)N(C)c2ccc(N)cc2)CC1
4-[N—(N-methylpiperazinomethylcarbonyl)-N-methyl-amino]-aniline
[Na+].[OH-]
sodium hydroxide
→
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4ccc([N+](=O)[O-])cc43)c3ccccc3)cc2)CC1
(Z)-3-{-[4-(N—(N-methylpiperazinomethylcarbonyl)-N-methyl-amino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone

Réactifs

CCOC(=C1C(=O)N(C(C)=O)c2ccc([N+](=O)[O-])cc21)c1ccccc1
1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone
CN1CCN(CC(=O)N(C)c2ccc(N)cc2)CC1
4-[N—(N-methylpiperazinomethylcarbonyl)-N-methyl-amino]-aniline
[Na+].[OH-]
sodium hydroxide

Réactifs

Aucun

Solvants

CN(C)C=O
DMF
CO
methanol

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Prepared analogously to Example 82 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 4-[N—(N-methylpiperazinomethylcarbonyl)-N-methyl-amino]-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06855710B2uspto-grants-2005_02