Réaction #53095

ord-da4a4b94bf6b4830867aae22a434a1d2

Équation de réaction

CCOC(=C1C(=O)N(C(C)=O)c2ccc([N+](=O)[O-])cc21)c1ccccc1
1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone
CN(C(=O)CN1CCOCC1)c1ccc(N)cc1
4-(N-morpholinomethylcarbonyl-N-methyl-amino)-aniline
[Na+].[OH-]
sodium hydroxide
→
CN(C(=O)CN1CCOCC1)c1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1
(Z)-3-{1-[4-(N-morpholinomethylcarbonyl-N-methyl-amino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone

Réactifs

CCOC(=C1C(=O)N(C(C)=O)c2ccc([N+](=O)[O-])cc21)c1ccccc1
1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone
CN(C(=O)CN1CCOCC1)c1ccc(N)cc1
4-(N-morpholinomethylcarbonyl-N-methyl-amino)-aniline
[Na+].[OH-]
sodium hydroxide

Réactifs

Aucun

Solvants

CN(C)C=O
DMF
CO
methanol

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Prepared analogously to Example 82 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 4-(N-morpholinomethylcarbonyl-N-methyl-amino)-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06855710B2uspto-grants-2005_02