Réaction #53056

Équation de réaction

(Z)-3-{1-[4-(N—(N-benzylpiperazinomethylcarbonyl)-N-methylamino)-phenylamino]-1-phenyl-methylidene}-2-indolinone

1-chloroethyl chloroformate

→

(Z)-3-{1-[4-(N-piperazinomethylcarbonyl-N-methyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone-dihydrochloride

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   Températurerefluxed for 60 minutes
2. 2
   ConcentrationThe solvent is concentrated by evaporation
3. 3
   Températurerefluxed for 90 minutes
4. 4
   Filtrationfiltered
5. 5
   Lavagewashed with methanol
6. 6
   Autredried

Mode opératoire

390 mg (0.7 mmol) of (Z)-3-{1-[4-(N—(N-benzylpiperazinomethylcarbonyl)-N-methylamino)-phenylamino]-1-phenyl-methylidene}-2-indolinone are dissolved in 20 ml of dichloromethane and after the addition of 0.2 g (1.4 mmol) of 1-chloroethyl chloroformate heated for 30 minutes at ambient temperature and refluxed for 60 minutes. The solvent is concentrated by evaporation, the residue is combined with 10 ml of methanol and refluxed for 90 minutes. After 18 hours stirring at ambient temperature, the product is suction filtered, washed with methanol and dried.

Source