Réaction #53055

ord-3e12fbf57bf84322ba5aa6308801d045

Équation de réaction

CCOC(=C1C(=O)N(C(C)=O)c2ccccc21)c1ccccc1
1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone
CN(C(=O)CN1CCN(Cc2ccccc2)CC1)c1ccc(N)cc1
4-[N-(4-benzylpiperazinomethylcarbonyl)-N-methylamino]-aniline
[Na+].[OH-]
sodium hydroxide
→
CN(C(=O)CN1CCN(Cc2ccccc2)CC1)c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1
(Z)-3-{1-[4-(N-(4-benzylpiperazinomethylcarbonyl)-N-methyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone

Réactifs

CCOC(=C1C(=O)N(C(C)=O)c2ccccc21)c1ccccc1
1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone
CN(C(=O)CN1CCN(Cc2ccccc2)CC1)c1ccc(N)cc1
4-[N-(4-benzylpiperazinomethylcarbonyl)-N-methylamino]-aniline
[Na+].[OH-]
sodium hydroxide

Réactifs

Aucun

Solvants

CN(C)C=O
DMF
CO
methanol

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Prepared analogously to Example 43 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone and 4-[N-(4-benzylpiperazinomethylcarbonyl)-N-methylamino]-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06855710B2uspto-grants-2005_02