Réaction #528484

Équation de réaction

5'-[(2,4-diamino-5-pyrimidinyl)methyl]3'-dimethylamino-2'-methoxy-N-methylacetanilide

hydrochloric acid

→

2,4-diamino-5-[3-dimethylamino-4-methoxy-5-(methylamino)benzyl]pyrimidine

Conditions de réaction

Traitement

1. 1
   Températureunder reflux for 2 hours
2. 2
   AutreAfter neutralization and evaporation
3. 3
   Autrein vacuo, purification of the residue over silica gel
4. 4
   Autrewith methylene chloride/propanol (8:2) and recrystallization from ethanol

Mode opératoire

4.0 G. of 5'-[(2,4-diamino-5-pyrimidinyl)methyl]3'-dimethylamino-2'-methoxy-N-methylacetanilide (prepared as described in the first paragraph of Example 2) and 100 ml. of 1-N hydrochloric acid were boiled under reflux for 2 hours. After neutralization and evaporation in vacuo, purification of the residue over silica gel with methylene chloride/propanol (8:2) and recrystallization from ethanol, there was obtained 2,4-diamino-5-[3-dimethylamino-4-methoxy-5-(methylamino)benzyl]pyrimidine, having a melting point of 183° C.

Source