Réaction #52800

Équation de réaction

5-chlorosulfonyl-2-oxindole

isopropylamine

pyridine

→

5-isopropylaminosulfonyl-2-oxindole

Rendement 45.5%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   FiltrationThe solid was collected by vacuum filtration
2. 2
   Lavageslurry-washed with hot ethanol
3. 3
   Températurecooled
4. 4
   Filtrationcollected by vacuum filtration and vacuum
5. 5
   Autredried at 40° C.

Mode opératoire

A suspension of 3 g of 5-chlorosulfonyl-2-oxindole, 1.15 g of isopropylamine and 1.2 mL of pyridine in 50 mL of dichloromethane was stirred at room temperature for 4 hours at which time a white solid was present. The solid was collected by vacuum filtration, slurry-washed with hot ethanol, cooled, collected by vacuum filtration and vacuum dried at 40° C. to give 1.5 g (45%) of 5-isopropylaminosulfonyl-2-oxindole.

Source