Réaction #527426

Équation de réaction

hydrogen

1-(3-nitro-2-pyridyl)piperazine

→

1-(3-amino-2-pyridyl)piperazine

Rendement 95.8%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added
2. 2
   Autrewas passed through for one hour
3. 3
   FiltrationThe reaction mixture was filtered
4. 4
   Concentrationthe filtrate was concentrated under reduced pressure

Mode opératoire

In 30 ml of methanol was dissolved 3.13 g (0.015 mole) of 1-(3-nitro-2-pyridyl)piperazine, and 2 g of 5% palladium carbon was added thereto. While stirring the mixture at room temperature, hydrogen gas was passed through for one hour. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain 2.56 g of 1-(3-amino-2-pyridyl)piperazine as pale yellow liquid.

Source