Réaction #52083

Équation de réaction

2,6-di-tert-butylhydroquinone

hexane

acetic anhydride

sulfuric acid

→

1,4-diacetoxy-2,6-di-tert-butylbenzene

Solvants

ethyl acetate

water

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was cooled to 10° C.
2. 2
   workup.STIRRINGthe mixture was stirred overnight
3. 3
   AutreThe solution was subjected to liquid-liquid separation
4. 4
   Lavagethereafter, the organic layer was washed with 40 mL of 7.5% aqueous sodium hydrogencarbonate and 40 mL of 10% aqueous sodium chloride
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

Mode opératoire

To the 2,6-di-tert-butylhydroquinone obtained in Example 10, 50 mL of hexane, 13.92 g (136.5 mmol) of acetic anhydride and 0.79 g (8.06 mmol) of sulfuric acid were added and the mixture was stirred for 2 hours at 50° C. The mixture was cooled to 10° C. and after adding 30 mL of water and 10 mL of ethyl acetate, the mixture was stirred overnight. The solution was subjected to liquid-liquid separation and the aqueous layer was discarded; thereafter, the organic layer was washed with 40 mL of 7.5% aqueous sodium hydrogencarbonate and 40 mL of 10% aqueous sodium chloride and the solvent was distilled off under reduced pressure to give 1,4-diacetoxy-2,6-di-tert-butylbenzene.

Source