Réaction #52043

Équation de réaction

4-chloro-3-nitro-quinoline

isobutyl amine

triethylamine

→

4-isobutyl-3-nitro quinoline

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   LavageAfter washing
2. 2
   Autrephase separation

Mode opératoire

4-chloro-3-nitro-quinoline is reacted with isobutyl amine in the presence of triethylamine (TEA) at between −10 and +15° C. in toluene, while excluding moisture. After washing and phase separation, the organic solution is ready for the next step.

Source