Réaction #51774

Équation de réaction

6-tert-butyl-1H-indole-2-carboxylic acid ethyl ester

ammonium thiocyanate

bromine

→

title compound

6-tert-Butyl-5-thiocyanato-1H-indole-2-carboxylate ethyl ester

Solvants

MeOH

Conditions de réaction

Traitement

1. 1
   AutreThe crude product was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

Mode opératoire

The title compound was prepared according to General Method 13 using 6-tert-butyl-1H-indole-2-carboxylic acid ethyl ester (prepared in Example YY; 3.5 g, 14 mmol), ammonium thiocyanate (1.63 g, 21.4 mmol), bromine (3.42 g, 21.4 mmol), and MeOH (50 mL). The crude product was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 301 (M−H).

Source