Réaction #51762

Équation de réaction

bromine

5-isopropyl-2-nitro-phenylamine

sodium thiocyanate

sodium bromide

→

title compound

5-Isopropyl-2-nitro-4-thiocyanato-phenylamine

Solvants

MeOH

Conditions de réaction

Traitement

1. 1
   AutreThe crude reaction mixture
2. 2
   Autrewas purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

Mode opératoire

The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).

Source