Réaction #51720

Équation de réaction

acetonitrile

4-methyl-5-thiazolecarbaldehyde

(3-methyl-2-oxobutyl)triphenylarsonium bromide

potassium carbonate

→

title compound

4-Methyl-1-(4-methyl-thiazol-5-yl)-pent-1-en-3-one

Solvants

H2O

Conditions de réaction

Traitement

1. 1
   AutreThe title compound was prepared
2. 2
   LavageChromatography of the residue, eluting with 3:1 hexane

Mode opératoire

The title compound was prepared as described in General Method 1 using 1.4 g (11.0 mmol) of 4-methyl-5-thiazolecarbaldehyde (Example A-12), 6.2 g (13.1 mmol) of (3-methyl-2-oxobutyl)triphenylarsonium bromide, 1.8 g (13.1 mmol) of potassium carbonate, 75 mL of acetonitrile, and 0.75 mL of H2O. Chromatography of the residue, eluting with 3:1 hexane:EtOAc gave the title compound.

Source