Réaction #51477

Équation de réaction

homopiperonylamine hydrochloride

triethylamine

chloroacetyl chloride

→

2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide

Rendement 74.5%

Solvants

CH2Cl2

Conditions de réaction

Traitement

1. 1
   Autrethe reaction was partitioned with 1 N HCl
2. 2
   AutreThe organic layer was separated
3. 3
   Lavagewashed with aqueous bicarbonate
4. 4
   Séchagedried (Na2SO4)
5. 5
   Autrethe solvent was removed in vacuo

Mode opératoire

To homopiperonylamine hydrochloride (2.14 g, 10.6 mmol) (a compound of formula (Y7)) in CH2Cl2 (20 mL) in an ice bath was added triethylamine (3.1 mL, 21 mmol) and chloroacetyl chloride (0.85 mL, 10 mmol) (a compound of formula (Y6)). After warming to ambient temperature and stirring for 16 hours, the reaction was partitioned with 1 N HCl. The organic layer was separated, washed with aqueous bicarbonate, dried (Na2SO4), and the solvent was removed in vacuo to give 1.8 g of 2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Y8).

Source