Réaction #51459

Équation de réaction

5-chlorocarbonylphthalid

dimethylamine

→

5-(N,N-dimethylcarbamyl)phthalid

Solvants

THF

Conditions de réaction

Traitement

1. 1
   AutreTHF is evaporated off in vacuo
2. 2
   Autreprecipitated crystals
3. 3
   Autreare filtred off at 5° C.
4. 4
   Lavagewashed with water (100 ml)

Mode opératoire

A solution of 5-chlorocarbonylphthalid (32 g, 0.16 mole) in THF (300 ml) is added to dimethylamine (40% v/v in water, 300 ml) and ice (100 g). The mixture is stirred for 1 hour. THF is evaporated off in vacuo and precipitated crystals are filtred off at 5° C. and washed with water (100 ml).

Source