Réaction #5144

Équation de réaction

2-(2-(2-chloroethoxy)ethoxy)-ethanol

m-nitrophenol

N,N-dimethylformamide

potassium carbonate

→

2-(2-(2-(3-nitrophenoxy)ethoxy)ethoxy)ethanol

Solvants

water

ethyl acetate

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGAfter stirring the mixture for one hour at 80° C.
2. 2
   Extractionthe ethyl acetate layer was extracted
3. 3
   LavageThe ethyl acetate layer was washed with 200 ml of water
4. 4
   Concentrationconcentrated
5. 5
   Autreto remove ethyl acetate

Mode opératoire

While stirring a mixture of 27.8 g of m-nitrophenol, 120 ml of N,N-dimethylformamide, and 25 g of potassium carbonate at 80° C., 37 g of 2-(2-(2-chloroethoxy)ethoxy)-ethanol was added dropwise to the mixture. After stirring the mixture for one hour at 80° C., 200 ml of ethyl acetate and 200 ml of water were added to the reaction mixture and the ethyl acetate layer was extracted. The ethyl acetate layer was washed with 200 ml of water and concentrated to remove ethyl acetate to provide 2-(2-(2-(3-nitrophenoxy)ethoxy)ethoxy)ethanol (1-A).

Source