Réaction #51386

ord-37729bb4c6894c8b993186f8256bc5ed

Équation de réaction

O=C(O)Cc1cccc([N+](=O)[O-])c1
3-nitrophenylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride
→
CC(C)COC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1
title compound
CC(C)COC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1
N-[(3-nitrophenyl)acetyl]-L-alanine iso-butyl ester

Réactifs

O=C(O)Cc1cccc([N+](=O)[O-])c1
3-nitrophenylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreThe reaction was monitored by tlc on silica gel and purification
  2. 2
    Autrewas by recrystallization from butyl chloride

Mode opératoire

Following General Procedure BH above and using 3-nitrophenylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by recrystallization from butyl chloride.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06849650B2uspto-grants-2005_02