Réaction #5127

ord-4bb73f6b08114a6bb1231cd70986f4d3

Équation de réaction

I.I.N=C(N)N(CCCCCCCCNCCCCCCCCC1CCCCC1)C1CCCCC1
1,17-biscyclohexylguanidino-9-azaheptadecane dihydroiodide
CO.O
methanol water
CC(=O)O.CC(=O)O.CC(=O)O.N=C(N)N(CCCCCCCCNCCCCCCCCC1CCCCC1)C1CCCCC1
guanidine
CC(=O)O.CC(=O)O.CC(=O)O.N=C(N)N(CCCCCCCCNCCCCCCCCC1CCCCC1)C1CCCCC1
1,17-Biscyclohexylguanidino-9-azaheptadecane triacetate

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

10.2 g (0.011 mol) of 1,17-biscyclohexylguanidino-9-azaheptadecane dihydroiodide in 150 ml of methanol/water (1:1) were filtered through a column containing 250 g of ion exchanger (OH- form). The free guanidine base obtained after working up was dissolved in methanol and converted into the triacetate with excess glacial acetic acid.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05242948uspto-grants-1993_09