Réaction #51243

Équation de réaction

(5R)-5-(hydroxymethyl)pyrrolidin-2-one

ethyl vinyl ether

trifluoroacetic acid

→

(5R)-5-(1-ethoxyethoxymethyl)pyrrolidin-2-one

Rendement 102.0%

Solvants

chloroform

Conditions de réaction

Traitement

1. 1
   Autrethe reaction was partitioned between methylene chloride (150 mL) and aqueous sodium bicarbonate solution (150 mL)
2. 2
   Autrethe phases were separated
3. 3
   SéchageThe organic phase was dried (K2CO3)
4. 4
   Filtrationfiltered
5. 5
   AutreThe filtrate was evaporated under reduced pressure

Mode opératoire

To a solution of (5R)-5-(hydroxymethyl)pyrrolidin-2-one (Aldrich, 8.86 g, 77 mmol) in 70 mL of chloroform at room temperature under an argon atmosphere was added ethyl vinyl ether (10.4 mL, 108 mmol) and catalytic anhydrous trifluoroacetic acid (0.2 mL). After stirring for 3 hours, the reaction was partitioned between methylene chloride (150 mL) and aqueous sodium bicarbonate solution (150 mL) and the phases were separated. The organic phase was dried (K2CO3) and filtered. The filtrate was evaporated under reduced pressure to give 14.7 g of the (5R)-5-(1-ethoxyethoxymethyl)pyrrolidin-2-one.

Source