Réaction #51242

Équation de réaction

sodium bicarbonate

ethyl glycolate

sodium hydride

1,4-dibromobutane

→

(4-Bromo-butoxy)-acetic Acid Ethyl Ester

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   Séchagethe organic layer was dried over anhydrous sodium sulfate
2. 2
   Concentrationconcentrated
3. 3
   Autrethe residue was purified by chromatography
4. 4
   Autreto afford a colorless oil

Mode opératoire

To a solution of sodium hydride in 40 mL DMF stirred at 0° C. was slowly added ethyl glycolate (5 g, 48 mmol). After 1 hour, 1,4-dibromobutane (8.6 mL, 72 mmol) was added, and the mixture was stirred for an additional 2 hours. The reaction was allowed to warm to room temperature for an additional 3 hours. A sodium bicarbonate solution was added, and the organic layer was dried over anhydrous sodium sulfate, concentrated and the residue was purified by chromatography to afford a colorless oil.

Source