Réaction #511488

Équation de réaction

(2S)-2-methylbutan-1-ol

triethylamine

methanesulfonyl chloride

→

(2S)-2-methylbutyl methanesulfonate

Solvants

THF

THF

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwise added
2. 2
   workup.ADDITIONAfter complete addition (15 min) the reaction mixture
3. 3
   workup.WAITfor 30 min at 0° C
4. 4
   FiltrationIt was then filtered over celite
5. 5
   Autreevaporated to dryness

Mode opératoire

To a −25° C. cooled solution of (2S)-2-methylbutan-1-ol (8.8 g) and triethylamine (30 ml) in THF (50 ml), a solution of methanesulfonyl chloride (1.14 g) in THF (10 ml) was drop wise added. After complete addition (15 min) the reaction mixture was further stirred for 2 h at −10° C. then for 30 min at 0° C. It was then filtered over celite and evaporated to dryness to give nearly pure (2S)-2-methylbutyl methanesulfonate as yellowish oil.

Source